Indications of Tissue Specificity

That certain aspects of susceptibility to transplantable tumors are genetic phenomena has been demonstrated in the case of a carcinoma and a sarcoma of the Japanese Waltzing micel 2 and in two mammary adenocarcinomata occurring in a special strain of highly inbred common domestic mice. 4,5 The acceptance of the view that susceptibility to transplanted neoplasms is fundamentally a genetic problem encounters an obstacle in those transplantable tumors which grow in all inoculated individuals, irrespective of the strain of mice employed. This is particularly true of a sarcoma transplanted at the George Crocker Research Laboratory Fund, Columbia University, and designated as No. 180, a tumor which grows almost uniformly in a number of different strains of laboratory mice from several sources. The following experiments have been carried out, not so much for the purpose of discovering a race resistant to this tumor, although that was the original intention, as to determine whether there are any indications of genetic phenomena associated with its transplantability. About 400 mice have been employed, a number insufficient for conclusive data, but as the work has been unavoidably interrupted, it seems advisable to present the data as they stand at present.